This is in five sections:
1. CGRP papers.
2. Other headache interventions.
3. Papers that inform community and primary care service delivery.
4. Miscellaneous papers of interest.
5. Useful publications.
Barbosa da Silva, Marina, et al. "Efficacy and safety of galcanezumab for cluster headache preventive treatment: a systematic review and meta-analysis." Neurological Research 47.1 (2025): 63-76.
Galcanezumab a safe and effective drug for cluster
Sharon, Jeffrey D., et al. "A placebo controlled, randomized clinical trial of galcanezumab for vestibular migraine: the INVESTMENT study." Headache: The Journal of Head and Face Pain 64.10 (2024): 1264-1272.
Galcanezumab is effective in vestibular migraine
Dodick, David W., et al. "Association of Oral Triptans and Other Oral Migraine Treatments With Cardiovascular Outcomes in Patients With a History of Cardiovascular Conditions." medRxiv (2025): 2025-01.
Reassuring data for Triptans in people with existing cardio vascular disease.
Øie, Lise Rystad, et al. "Candesartan versus placebo for migraine prevention in patients with episodic migraine: a randomised, triple-blind, placebo-controlled, phase 2 trial." The Lancet Neurology 24.10 (2025): 817-827.
Candasarten is safe and effective at 16mg.
Kernick, David, et al. "Preventive treatment patterns in the adult migraine population: an observational UK study over 7 years." BMC Primary Care 25.1 (2024): 34.
Large data base study of prevention use and switching in general practice. 42% of migraineurs had used prevention. Only 21% of three treatment failures were referred to specialist care.
Collings, S., et al. "The cost of migraine to the NHS in England: a retrospective cohort study using electronic health record data from Clinical Practice Research Datalink (CPRD) and Hospital Episode Statistics (HES)." Current Medical Research and Opinion 41.9 (2025): 1641-1653.
Soe useful data about management in primary care prior to consultant referral
Rees, Tayla A., et al. "Neck pain in migraine: A narrative review and steps to correct evaluation and treatment." Cephalalgia 45.10 (2025): 03331024251387449.
Migraine and the bidirectional relationship with neck pain.
Rees, Tayla A., et al. "Neck pain in migraine: A narrative review and steps to correct evaluation and treatment." Cephalalgia 45.10 (2025): 03331024251387449.
Migraine and the bidirectional relationship with neck pain.
Ashina, Messoud, et al. "A monoclonal antibody to PACAP for migraine prevention." New England Journal of Medicine 391.9 (2024): 800-809.
The next target?
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